abstract：:Estrogen deficiency in females and androgen deficiency in males may harm periosteal and endosteal apposition, reduce bone size and both cortical and trabecular thickness, modifying in this way the bone structure later in life. To date, few systematic studies on bone mineral density (BMD) and hypogonadism in adolescent...

journal_title：Journal of endocrinological investigation

authors： Fintini D,Grossi A,Brufani C,Fiori R,Ubertini G,Pecorelli L,Cappa M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A>G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated se...

journal_title：Journal of endocrinological investigation

authors： Labruna G,Pasanisi F,Nardelli C,Tarantino G,Vitale DF,Bracale R,Finelli C,Genua MP,Contaldo F,Sacchetti L

更新日期：2009-06-01 00:00:00

abstract：:Leptin, insulin, ghrelin, and IGF-I are circulating peptide hormones concerned with energy homeostasis and the regulation of GH axis. They are present in human milk, and are thought to promote neonatal development. The aim of the present study was to detect these substances in goat milk and determine whether their lev...

journal_title：Journal of endocrinological investigation

authors： Rosi F,Aufy AA,Magistrelli D

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Interleukins and cytokines play an important role in the pathogenesis of many cancers.We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in patients with papillary thyroid carcinoma (PTC) and control subjects. MATERIAL AND METHODS:In this study, 42 patients with PTC and 340 healthy controls we...

journal_title：Journal of endocrinological investigation

authors： Ozgen AG,Karadeniz M,Erdogan M,Berdeli A,Saygili F,Yilmaz C

更新日期：2009-06-01 00:00:00

abstract：AIMS AND METHODS:Factor analysis is a multivariate correlation technique frequently employed to characterise the aggregation of abnormalities underlying the metabolic syndrome (MS), but scarcely used in obese adolescents. Aim of the study was to investigate the clustering of anthropometric and metabolic variables relat...

journal_title：Journal of endocrinological investigation

authors： Lafortuna CL,Adorni F,Agosti F,De Col A,Zennaro R,Caranti D,Sartorio A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:In vitro data have shown conflicting results in terms of the effect of leptin on granulosa cells steroidogenesis. AIM:The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. MATERI...

journal_title：Journal of endocrinological investigation

authors： Karamouti M,Kollia P,Kallitsaris A,Vamvakopoulos N,Kollios G,Messinis IE

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate the differences in emotional and behavioral problems and to explore the association between the level of psychiatric problems and the metabolic control in Type 1 diabetes. METHODS:The children with Type 1 diabetes (no.=42) and the "healthy" control group (no.=42), their parents and en...

journal_title：Journal of endocrinological investigation

authors： Akbaş S,Karabekiroğlu K,Ozgen T,Tasdemir G,Karakurt M,Senses A,Böke O,Aydin M

更新日期：2009-04-01 00:00:00

abstract：:Pheochromocytoma resection is often complicated by intra-operative hypertension and post-resection hypotension. Factors associated with these hemodynamic alterations are not well defined. The aim of this study was to analyse the clinical-laboratory features associated with hemodynamic parameters during pheochromocytom...

journal_title：Journal of endocrinological investigation

authors： Kramer CK,Leitão CB,Azevedo MJ,Canani LH,Maia AL,Czepielewski M,Paggi A,Rodrigues TC,Silveiro SP,Friedman R,Gross JL

更新日期：2009-03-01 00:00:00

abstract：:Resistance to thyroid hormone (RTH) is a rare disease characterized by non-suppressed TSH in spite of high free thyroid hormone levels. Up to date, in the literature, there are more than 600 RTH cases, but co-incidental hypophyseal adenoma was reported in only 1 case. In the literature, despite reported cases with thy...

journal_title：Journal of endocrinological investigation

authors： Berker D,Aydin Y,Tutuncu YA,Isik S,Delibasi T,Berker M,Guler S,Kamel N

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The aim of this study is to analyze our preliminary results from minimally invasive video-assisted parathyroidectomy (MIVAP) and demonstrate the feasibility of MIVAP also in non-referral centers. MATERIAL AND METHODS:During a period from June 2005 to January 2008, in the General Surgery Department of Univer...

journal_title：Journal of endocrinological investigation

authors： Dobrinja C,Trevisan G,Liguori G

更新日期：2009-02-01 00:00:00

abstract：:Homocysteine (HCY) is a sulfur-containing amino acid involved in two metabolic pathways, catalized by cystathionine-B-synthase and methionine synthase, depending on vitamin (vit) B6, B12, and folate levels and enzymatic activity of methylenetetrahydrofolate. High HCY levels (HHCY) are associated with cardiovascular (C...

journal_title：Journal of endocrinological investigation

authors： Petramala L,Acca M,Francucci CM,D'Erasmo E

更新日期：2009-01-01 00:00:00

abstract：AIM:This 3-month study compared the effect on overall glycemic control of adding biphasic insulin aspart 30 (BIAsp30) and premixed human insulin 30/70 (BHI30) to metformin (met) in insulin-naïve, obese patients (30 males/20 females) with Type 2 diabetes (T2DM). MATERIAL/SUBJECTS: At baseline, patients had a mean age of...

journal_title：Journal of endocrinological investigation

authors： Velojic-Golubovic M,Mikic D,Pesic M,Dimic D,Radenkovic S,Antic S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Results of circulating Ghrelin levels in hyper- or hypothyroidism are conflicting and only overt thyroid dysfunction has been evaluated. AIM:To evaluate in a large number of patients with thyroid disfunction whether: a) hyper- and hypothyroidism (clinical or subclinical) are associated with variations in bo...

journal_title：Journal of endocrinological investigation

authors： Tanda ML,Lombardi V,Genovesi M,Ultimieri F,Lai A,Gandolfo M,Dalle Mule I,Grasso L,Bogazzi F,Broglio F,Ghigo E,Martino E,Bartalena L

更新日期：2009-01-01 00:00:00

abstract：:General dynamic penile color doppler ultrasound (D-PCDU) screening in patients with erectile dysfunction (ED) has been questioned due to an inadequate cost-benefit ratio. The aim of the present study is to evaluate the validity of different risk scores in the identification of patients being screened for arteriogenic ...

journal_title：Journal of endocrinological investigation

authors： Corona G,Mannucci E,Fisher AD,Lotti F,Bandini E,Vignozzi L,Balercia G,Paggi F,Petrone L,Forti G,Maggi M

更新日期：2008-12-01 00:00:00

abstract：:Dopamine agonists have been associated with increased risk of cardiac valve regurgitation in patients with Parkinson's disease. Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled. Occasional case reports and 7 studies on the relationship between cabergoline and cardiac valve r...

journal_title：Journal of endocrinological investigation

authors： Bogazzi F,Manetti L,Raffaelli V,Lombardi M,Rossi G,Martino E

更新日期：2008-12-01 00:00:00

abstract：:No head-to-head comparisons are available to analyze the efficacy of octreotide (LAR) and lanreotide (LAN) as first-line treatment of acromegaly.We compared the efficacy of these two drugs in 54 newly diagnosed patients (21 women, 33 men), 27 treated with LAR (10-30 mg every 28 days) and 27 with LAN (60-90 mg/28 days)...

journal_title：Journal of endocrinological investigation

authors： Auriemma RS,Pivonello R,Galdiero M,De Martino MC,De Leo M,Vitale G,Lombardi G,Colao A

更新日期：2008-11-01 00:00:00

abstract：:This study examined the association of depression, anxiety, and stress with Type 2 diabetes (T2DM) in Bahrain, an island-country with a very high prevalence of T2DM. This was a cross-sectional study involving administering Depression Anxiety Stress Scales (DASS)-21 structured depression, anxiety, and stress scale to 1...

journal_title：Journal of endocrinological investigation

authors： Almawi W,Tamim H,Al-Sayed N,Arekat MR,Al-Khateeb GM,Baqer A,Tutanji H,Kamel C

更新日期：2008-11-01 00:00:00

abstract：:Antithyroid drugs may be proposed as the firstline therapy for hyperthyroidism due to Graves' disease since some patients undergo prolonged remission after drug withdrawal. On the other hand, some studies, though controversial, indicated that methimazole (MMI) has some immunomodulating activity. We retrospectively ana...

journal_title：Journal of endocrinological investigation

authors： Mazza E,Carlini M,Flecchia D,Blatto A,Zuccarini O,Gamba S,Beninati S,Messina M

更新日期：2008-10-01 00:00:00

abstract：:Data concerning the cardiovascular manifestations of primary hyperparathyroidism (PHPT) are inconsistent, which is due, in part, to the decrease in disease severity over the last several decades. In areas where patients tend to be more symptomatic, data support the presence of cardiovascular findings including myocard...

journal_title：Journal of endocrinological investigation

authors： Walker MD,Silverberg SJ

更新日期：2008-10-01 00:00:00

abstract：:Stroke is one of the main causes of death and disability in the adult population. Changes in pituitary hormone secretion may be observed during the acute phase of stroke, representing part of the adaptive response to injury. However, reduced pituitary hormone secretion, caused by pituitary and/or hypothalamus damage, ...

journal_title：Journal of endocrinological investigation

authors： Bondanelli M,Ambrosio MR,Zatelli MC,Basaglia N,Degli Uberti EC

更新日期：2008-09-01 00:00:00

abstract：:Central hypothyroidism (CH) is a rare cause of hypothyroidism characterized by a defect of thyroid hormone production due to an insufficient TSH stimulation. CH can be congenital in the case of genetic defects or acquired in the case of lesions affecting either pituitary or hypothalamus. Diagnosis is usually made on a...

journal_title：Journal of endocrinological investigation

authors： Lania A,Giavoli C,Ferrante E,Beck-Peccoz P

更新日期：2008-09-01 00:00:00

abstract：:Severe vitamin D deficiency has been found to be prevalent in institutionalized elderly persons in several countries. The aim of the present work was to assess the vitamin D status of institutionalized elderly and compare it to that of community-living independent elderly in southern Greece during summer. Serum 25-hyd...

journal_title：Journal of endocrinological investigation

authors： Papapetrou PD,Triantafyllopoulou M,Korakovouni A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A v...

journal_title：Journal of endocrinological investigation

authors： Kim SY,Lim JH,Yang JH,Kim MY,Kim MH,Park SY,Ryu HM

更新日期：2008-08-01 00:00:00

abstract：:Papillary thyroid cancer (PTC) accounts for 80% of all thyroid malignancies, and genetic alterations associated to its etiology remain largely unknown. Chromosomal band 11q13 seems to be one of the most frequently amplified regions in human cancer, providing several candidate genes that need detailed characterization....

journal_title：Journal of endocrinological investigation

authors： Hidalgo M,Saez ME,Martinez-Tello FJ,Moron FJ,Ferrero-Herrero E,Labalde-Martinez M,Rigopoulou D,Ballestin-Carcavilla C,Ruiz A,Royo JL,Ramirez-Lorca R

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To our knowledge, no case of remission in autoimmune Addison's disease has previously been reported. We describe a patient with primary adrenal insufficiency caused by autoimmune adrenalitis in whom partial remission was observed after 7 yr. CASE:A 39-yr-old male was referred because of extreme fatigue, weig...

journal_title：Journal of endocrinological investigation

authors： Smans LC,Zelissen PM

更新日期：2008-07-01 00:00:00

abstract：:Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. GC influence bone metabolism via a modulation of different components of the GH/IGF-I system. GH has multiple anabolic effects on bone, either direct or mediated by IGF-I. GH-deficient subjects have significant reduction in bo...

journal_title：Journal of endocrinological investigation

authors： Lombardi G,Colarusso S,Di Somma C,Guerra E,Tauchmanova L,Colao A

更新日期：2008-07-01 00:00:00

abstract：AIM:Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are ...

journal_title：Journal of endocrinological investigation

authors： Bo S,Gambino R,Durazzo M,Ghione F,Musso G,Gentile L,Cassader M,Cavallo-Perin P,Pagano G

更新日期：2008-06-01 00:00:00

abstract：:We investigated the presence of mutations/polymorphisms in the FSH receptor (FSHR) gene and their association with phenotype in women with premature ovarian failure (POF) in southern Brazil. Clinical and hormonal variables were determined in 36 46,XX women with primary or secondary amenorrhea before the age of 40 yr, ...

journal_title：Journal of endocrinological investigation

authors： Vilodre LC,Kohek MB,Spritzer PM

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Two yr after legislation of salt iodization of 40 parts per million (ppm) in 1994, goiter was still endemic and urinary iodine concentration (UIC) remained elevated in many provinces of Iran. Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian ho...

journal_title：Journal of endocrinological investigation

authors： Azizi F,Mehran L,Sheikholeslam R,Ordookhani A,Naghavi M,Hedayati M,Padyab M,Mirmiran P

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Chronic alcohol abuse is a risk factor for osteoporosis and fractures, whose pathogenesis is still unclear. We investigated the influence of alcoholism and other risk factors on calcium and skeletal metabolism, bone mineral density (BMD), and fractures. MATERIALS AND METHODS:In 51 chronic male alcoholics wi...

journal_title：Journal of endocrinological investigation

authors： Santori C,Ceccanti M,Diacinti D,Attilia ML,Toppo L,D'Erasmo E,Romagnoli E,Mascia ML,Cipriani C,Prastaro A,Carnevale V,Minisola S

更新日期：2008-04-01 00:00:00

abstract：:GH may exert direct growth-promoting and metabolic actions on target tissues, but most of its effects are mediated by circulating (endocrine) or local (auto-/paracrine) IGF-I. The GH/IGF-I system has an important role in cardiac development and in maintaining the structure and function of the heart. A subgroup of chil...

journal_title：Journal of endocrinological investigation

authors： Nygren A,Sunnegårdh J,Albertsson-Wikland K,Berggren H,Isgaard J

更新日期：2008-03-01 00:00:00

abstract：:Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pat...

journal_title：Journal of endocrinological investigation

authors： Gatzioufas Z,Thanos S

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (MSC) mediate their protection by paracrine mechanism under ischemic conditions and anoxic pre-conditioning (AP) of MSC strongly enhances their survival and regenerative capacity. However, there is no report about the therapeutic potency of MSC transplantation on diabetic c...

journal_title：Journal of endocrinological investigation

authors： Li JH,Zhang N,Wang JA

更新日期：2008-02-01 00:00:00

abstract：AIM:Adult subjects with Prader-Willi syndrome (PWS) may show several conditions that are associated with an activation of innate immunity such as obesity, deficient GH secretion or hypogonadism. Our aim was to study whether obese adult PWS subjects show an additional low-grade systemic inflammation (LGSI) in relation t...

journal_title：Journal of endocrinological investigation

authors： Caixàs A,Giménez-Palop O,Broch M,Vilardell C,Megía A,Simón I,Giménez-Pérez G,Mauricio D,Vendrell J,Richart C,González-Clemente JM

更新日期：2008-02-01 00:00:00

abstract：:The aim of the study was to examine the effects of strenuous training on the hypothalamic- pituitary-adrenal axis activity. Exercise tests and saliva collections for analysis of awakening cortisol response (ACR) and midnight cortisol were performed before and after a 7-day period of intensified training in a group of ...

journal_title：Journal of endocrinological investigation

authors： Minetto MA,Lanfranco F,Tibaudi A,Baldi M,Termine A,Ghigo E

更新日期：2008-01-01 00:00:00

abstract：:Subclinical hypothyroidism (SH) is a common clinical problem, particularly in adulthood and the elderly. Its prevalence is conditioned by several etiological and risk factors. The highest age- and sex-specific rates are in women over 60. SH may be associated with manifestations of mild thyroid failure, which may rever...

journal_title：Journal of endocrinological investigation

authors： Arrigo T,Wasniewska M,Crisafulli G,Lombardo F,Messina MF,Rulli I,Salzano G,Valenzise M,Zirilli G,De Luca F

更新日期：2008-01-01 00:00:00

abstract：:Pendred syndrome is an autosomal recessive disorder characterized by congenital sensorineural deafness, goiter, and impaired iodide organification. It is caused by mutations in the PDS gene. Most published mutation studies of Pendred syndrome have dealt with Western populations. In this study, we examined clinical and...

journal_title：Journal of endocrinological investigation

authors： Snabboon T,Plengpanich W,Saengpanich S,Sirisalipoch S,Keelawat S,Sunthornyothin S,Khovidhunkit W,Suwanwalaikorn S,Sridama V,Shotelersuk V

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to determine the protein pattern of human thyroid fine needle aspiration fluid (FNA) using a proteomic approach. FNA proteins were separated using 2-dimensional gel electrophoresis (2DE), digested and then analyzed by peptide mass fingerprinting. For the first time, we provided an image of th...

journal_title：Journal of endocrinological investigation

authors： Giusti L,Iacconi P,Ciregia F,Giannaccini G,Basolo F,Donatini G,Miccoli P,Lucacchini A

更新日期：2007-11-01 00:00:00

abstract：:Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has r...

journal_title：Journal of endocrinological investigation

authors： Seoane LM,Al-Massadi O,Barreiro F,Dieguez C,Casanueva FF

更新日期：2007-10-01 00:00:00

abstract：:Anorexia nervosa (AN) is an eating disorder characterized by self-induced starvation due to fear of adiposity. Ghrelin, gastric peptide with potent orexigenic, adipogenic, GH-releasing and metabolic properties, is elevated in AN. We have previously shown that intervention with exogenous ghrelin is not effective in ter...

journal_title：Journal of endocrinological investigation

authors： Miljic D,Djurovic M,Pekic S,Doknic M,Stojanovic M,Milic N,Casanueva FF,Ghatei M,Popovic V

更新日期：2007-10-01 00:00:00